Recent Posts



No tags yet.

Clinical Studies - List of Updated Publications

The list is a selection of clinical studies published in peer reviewed journals is partly complete.


  1. Chung SL, Lin JY, Lo LW, Chung FP, Chao TF, Tuan TC, Liao JN, Lin CY, Chang YT, Chiou CW, Chen SA. Dynamic Change of Electromechanical Coupling and Left Ventricular Systolic Function in Patients With Normal Left Ventricular Ejection Fraction During Cardiac Arrhythmia. Heart Rhythm. 2015; 12 (5S): S465-6.


  1. Sung SH, Yu WC, Cheng HM, Chang YP, Chen CH. Use of Acoustic Cardiography to Guide Outpatient Therapy of Patients with Acute Heart Failure Syndrome. JACC. 2014; 63 (12) (supplement A): 1186-182.

  1. Beeler R, Schoenenberger AW, Bauer P, Kobza R, Bergner M, Mueller X, Schlaepfer R, Zuber M, Erne S, Erne P. Improvement of cardiac function with device-based diaphragmatic stimulation in chronic heart failure patients: the randomized, open-label, crossover Epiphrenic II Pilot Trial. Eur J Heart Fail. 2014;16(3):342-9.

  1. Wen YN, Lee AP, Fang F, Jin CN, Yu CM. Beyond auscultation: acoustic cardiography in clinical practice. Int J Cardiol. 2014;172(3):548-60.

  1. Xu Y, Zhou Y, Bao M, Lin H, Zhang W, Xu G. Diagnostic Value of Acoustic Cardiography in Chronic Systolic Heart Failure. Chin J Cardiac Arrhyth. 2014; 8(4):304-8.


  1. Wang S, Fang F, Liu M, Lam YY, Wang J, Shang Q, Sun JP, Sanderson JE, Yu CM. Rapid bedside identification of high-risk population in heart failure with reduced ejection fraction by acoustic cardiography. Int J Cardiol. 2013, 168(3):1881-6.

  1. Toggweiler S, Odermatt Y, Brauchlin A, Zander T, Müller A, Zuber M, Winterhalder R, Erne P. The clinical value of echocardiography and acoustic cardiography to monitor patients undergoing anthracycline chemotherapy. Clin Cardiol. 2013, 36 (4): 201-6.

  1. Chan W, Woldeyohannes M, Colman R, Arand P, Michales AD, Parker JD, Granton JT, Mak S. Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study. BMJ Open. 2013, 3:e002660.


  1. Dillier R, Baumann B, Young M, Erne S, Schwizer B, Zuber M, Erne P. Continuous Respiratory Monitoring for Sleep Apnea Screening by Ambulatory Hemodynamic Monitor. World J Cardiol, 2012, 4(4): 121-127.

  1. Wang S, Lam YY, Liu M, Fang F, Wang J, Shang Q, Sun JP, Sanderson JE, Yu CM. Acoustic Cardiography Helps to Identify Heart Failure and its Phenotypes. Int J Cardiol. 2013;167(3):681-6

  1. Jamshidi, P; Kobza R, Toggweiler S, Arand P, Zuber M, Erne P. Impact of Preload Changes on Positive and Negative Left-ventricular dP/dt and Systolic Time Intervals. Indian Heart Journal. 2012, 64(3): 314-318.


  1. Karabsheh S, Michaels AD. Acoustic Cardiographic Indices of Transmyocardial Ischemia During Percutaneous Coronary Intervention. Acute Cardiac Care. 2011, 13(1): 3-8.

  1. Dillier R, Zuber M, Arand P, Erne S, Erne P. Assessment of Systolic and Diastolic Function in Heart Failure Using Ambulatory Monitoring with Acoustic Cardiography. Annals of Medicine. 2011, 43(5): 403-411.

  1. Dillier R, Zuber M, Arand P, Erne S, Erne P. Assessment of Systolic and Diastolic Function in Asymptomatic Subjects using Ambulatory Monitoring with Acoustic Cardiography, Clinical Cardiology. 2011, 34(6): 384-388.

  1. Dillier R, Kobza, R, Erne S, Zuber M, Arand P, Erne P. Non-invasive Detection of Left-ventricular Systolic Dysfunction in Atrial Fibrillation. Cardiology Research and Practice. 2011.


  1. Zuber M, Roos M, Kobza, R, Toggweiler S, Meier R, Erne P. Detection and Hemodynamic Significance of Cardiac Pacemaker-Induced Phrenic Nerve Stimulation. Congestive Heart Failure. 2010, 16(4):147-152.

  1. Michaels AD, Khan FU, Moyers B. Experienced Clinicians Improve Detection of Third and Fourth Heart Sounds by Viewing Acoustic Cardiography. Clinical Cardiology. Published online Feb. 2, 2010 33(3):E36-42.

  1. Collins SP, Kontos M, Michaels AD, Zuber M, Kipfer P, Jost CA, Roos M, Jamshidi P, Erne P, Lindsell CJ. Utility of a Bedside Acoustic Cardiographic Model to Predict Elevated Left Ventricular Filling Pressure. Emerg Med J. 2010, 27:677-682.

  1. Zuber M, Erne P. Acoustic cardiography to improve detection of coronary artery disease with stress testing. World J of Cardiology. 2010, 2(5): 118-124.

  1. Chao T, Sung S, Cheng H, Yu W, Wang K, Huang C, Chen C. Electromechanical Activation Time in the Prediction of Discharge Outcomes in Patients Hospitalized with Acute Heart Failure Syndrome. Internal Med. 2010, 49: 20312037.

  1. Gupta S, Gupta N, Arand P, Michaels AD. Computerized Acoustic Cardiography Correlates with Echocardiography and Invasive Hemodynamics after Percutaneous Transvenous Mitral Commissurotomy. J Med Eng Technol. Epub Nov 2 2010. 2011, 35(1): 59-64.

  1. Kosmicki DL, Collins SP, Kontos MC, Zuber M, Kipfer P, Attenhofer Jost C, Michaels AD. Non-invasive prediction of left ventricular systolic dysfunction in patients with clinically suspected heart failure using acoustic cardiography. Congestive Heart Failure. 2010. 16: 249-253.

  1. Dennis A, Michaels AD, Arand P, Ventura D. Noninvasive Diagnosis of Pulmonary Hypertension Using Heart Sound Analysis. Computers in Medicine and Biology. 2010. 40(9): 758-764.

  1. Maisel AS, Peacock WF, Shah KS, Clopton P, Diercks D, Hiestand B, Kontos MC, Mueller C, Nowak R, Chen WJ, Collins SP. Acoustic Cardiography S3 Detection Use in Problematic Subgroups and B-type Natriuretic Peptide “Gray Zone”: Secondary Results from the Heart Failure and Audicor Technology for Rapid Diagnosis and Initial Treatment Multinational Investigation. Am J Emergency Medicine. 2010. published online July, 2010.

  1. Taha N, Zhang J, Ranjan R, Daneshvar S, Castillo E, Guillen E, Montoya MC, Velasquez G, Naqvi TZ. Biventricular Pacemaker Optimization Guided by Comprehensive Echocardiography – Preliminary Observations Regarding the Effects on Systolic and Diastolic Ventricular Function and Third Heart Sound. J of the Am Soc of Echocardiography. 2010, 23(8): 857-866.

  1. McCullough PA, Zerka M, Heimbach E, Musialcyzk M, Spring T, Dejong A, Jafri SS, Coleman C, Washington T, Raheem S, Vanhecke T, Zalesin KC. Audiocardiography in the cardiovascular evaluation of the morbidly obese. Clin Physiol Funct Imaging, 2010, 30(5): 369-374.

  1. Hasan A. How Should Echocardiography Be Used in CRT Optimization? J of the Am Society of Echocardiography. 2010, 23(8): 867-871.


  1. Roos M, Kobza R, Jamshidi P, Bauer P, Resink T, Schlaepfer R, Stulz P, Zuber M, Erne P. Improved Cardiac Performance Through Pacing-induced Diaphragmatic Stimulation: A Novel Electrophysiological Approach in Heart Failure Management?. Europace. 2009; 11:191-199.

  1. Collins SP, Peacock FP, Lindsell CJ, Clopton P, Diercks D, Hiestand B, Hogan C, Kontos MC, Mueller C, Nowak R, Chen WJ, Huang CH, Abraham WT, Amsterdam E, Breidthardt T, Daniels L, Hasan A, Hudson M, McCord J, Naz T, Wagoner L, Maisel A. S3 Detection as a Diagnostic and Prognostic Aid in Emergency Department Patients with Acute Dyspnea: Primary Results from the HEARD-IT Multinational Investigation. Annals of Emergency Medicine. 2009; 53: 748-757.

  1. Lee E, Drew BJ, Selvester R, Michaels AD. Sequence of Electrocardiographic and Acoustic Cardiographic Changes and Angina During Coronary Occlusion and Reperfusion in Patients Undergoing Percutaneous Coronary Intervention. Annals of Non-Invasive Electrocardiology; 2009; 14(2):137-146.

  1. Gupta S., Michaels AD. Relationship Between Accurate Auscultation of the Fourth Heart Sound and Level of Physician Experience. Clinical Cardiology. 2009; 32(2):69-75.

  1. Lee E, Drew BJ, Selvester RH, Michaels AD, Diastolic Heart Sounds as an Adjunctive Diagnostic Tool with ST criteria for Acute Myocardial Ischemia, Acute Cardiac Care. Acute Cardiac Care. 2009; 11(4): 229-235.

  1. Collins SP, Lindsell CJ, Zuber M, Kontos MC, Kipfer P, Attenhofer Jost C, Kosmicki D, Michaels AD. Bedside Prediction of Increased Filling Pressure using Acoustic Electrocardiography. American Journal of Emergency Medicine. 2009; 27: 397-408

  1. Rogers RK, Stehlik J, Stoddard GJ, Greene T, Collins SP, Peacock WF, Maisel AD, Clopton P, Michaels AD. Adjusting for clinical covariates improves the ability of BNP to distinguish cardiac from non-cardiac dyspnea: a substudy of HEARD-IT. European Journal of Heart Failure, 2009. 11(1): 1043-1049.

  1. Collins SP, Lindsell CJ, Naftilan AJ, Peacock WF, Diercks D, et al. Low-Risk acute heart failure patients: external validation of the society of chest pain center's recommendations. Critical Pathways in Cardiology. 2009. 8(3): 99103.


  1. Lee E, Michaels AD, Selvester RH, Drew BJ. Frequency of Diastolic Third and Fourth Heart Sounds with Myocardial Ischemia Induced During Percutaneous Coronary Intervention. Journal of Electrocardiography 2008, 42(1): 39-45.

  1. Rogers RK, Collins SP, Kontos MC, Zuber M, Arand P, Michaels AD. Diagnosis and Characterization of Left Ventricular Hypertrophy by Computerized Acoustic Cardiography, Brain Natriuretic Peptide, and Electrocardiography. Journal of Electrocardiography 2008, 41(6):518-525.

  1. Erne P. Beyond Auscultation: Acoustic Cardiography in the Diagnosis and Assessment of Cardiac Disease. Swiss Medical Weekly. 2008; 138(31-32); 439-452.

  1. Zuber M, Toggweiler S, Quinn-Tate L, Brown L, Amkieh A, Erne P. A Comparison of Acoustic Cardiography and Echocardiography for Optimizing Pacemaker Settings in Cardiac Resynchronization Therapy. Pacing and Clinical Electrophysiology (PACE). 2008; Vol. 31 Issue No. 7:802-811.

  1. Kobza R, Roos M, Toggweiler S, Zuber M, Erne P. Recorded Heart Sounds for Identification of Ventricular Tachycardia. Resuscitation 2008 Nov; 79(2):265-72.

  1. Karabsheh S. Neuharth RM, Hamdan MH, Michaels AD. Acoustic Cardiographic Recording during Ventricular Fibrillation. Case Report. Resuscitation 2008; Vol 78: 374-377.

  1. Efstratiadis S, Michaels AD. Computerized Acoustic Cardiographic Electromechanical Activation Time Correlates with Invasive and Echocardiographic Parameters of Left Ventricular Contractility. Journal of Cardiac Failure (JCF) 2008; Vol. 14 Issue 7:577-582.

  1. Shah SJ, Nakamura K, Marcus G, Gerber I, McKeown B, Jordan M, Huddleston M, Foster E, Michaels A. Association of the Fourth Heart Sound with Increased Left Ventricular End-Diastolic Stiffness. Journal of Cardiac Failure (JCF) 2008; Vol. 14 No. 5:431-436.

  1. Roos M, Toggweiler S, Jamshidi P, Zuber M, Kobza R, Meier R, Erne P. Non-invasive Detection of Left-Ventricular Systolic Dysfunction by Acoustic Cardiography in Cardiac Failure Patients. Journal of Cardiac Failure (JCF) 2008; Vol. 14 No. 4:310-319.

  1. Zuber M, Toggweiler S, Roos M, Kobza R, Jamshidi P, Erne P. Comparison of Different Approaches for Optimization of Atrioventricular and Interventricular Delay in Biventricular Pacing. Europace 2008 Mar;10(3):367373.